240. AUTOIMMUNE RHEUMATIC DISEASE IMMUNOGLOBULIN G DIFFERENTIALLY REGULATES NEUTROPHIL INTEGRIN ACTIVATION AND NEUTROPHIL ACTIVATION
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چکیده
منابع مشابه
gm-csf differentially regulates eosinophil and neutrophil adhesive interactions with vascular endothelium in vivo
allergic airway inflammation is characterized by elaboration of cytokines and chemokines leading to recruitment of inflammatory leukocytes, predominantly eosinophils, to the airways. granulocyte macrophage colony stimulating factor (gm-csf) is generated in the lungs of human subjects with asthma in response to allergen challenge and is necessary for the development of allergen-induced bronchial...
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Integrin activation is required to facilitate multiple adhesion-dependent functions of neutrophils, such as chemotaxis, which is critical for inflammatory responses to injury and pathogens. However, little is known about the mechanisms that mediate integrin activation in neutrophils. We show that Radil, a novel Rap1 effector, regulates β1- and β2-integrin activation and controls neutrophil chem...
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Neutrophil arrest and migration on inflamed endothelium is dependent upon a conformational shift in CD11a/CD18 (LFA-1) from a low to high affinity and clustered state which determines the strength and lifetime of bond formation with intracellular adhesion molecule 1 (ICAM-1). Cytoskeletal adaptor proteins kindlin-3 and talin-1 anchor clustered LFA-1 to the cytoskeleton and support the transitio...
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Neutrophil recruitment, mediated by β2 integrins, combats pyogenic infections but also plays a key role in ischemia-reperfusion injury and other inflammatory disorders. Talin induces allosteric rearrangements in integrins that increase affinity for ligands (activation). Talin also links integrins to actin and other proteins that enable formation of adhesions. Structural studies have identified ...
متن کاملSemaphorin 4D inhibits neutrophil activation and is involved in the pathogenesis of neutrophil-mediated autoimmune vasculitis
OBJECTIVES Inappropriate activation of neutrophils plays a pathological role in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). The aim of this study was to investigate the functions of semaphorin 4D (SEMA4D) in regulation of neutrophil activation, and its involvement in AAV pathogenesis. METHODS Serum levels of soluble SEMA4D were evaluated by ELISA. Blood cell-surfac...
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ژورنال
عنوان ژورنال: Rheumatology
سال: 2017
ISSN: 1462-0324,1462-0332
DOI: 10.1093/rheumatology/kex062.242